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KMID : 0378120030300020245
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Chungnam Medical Journal
2003 Volume.30 No. 2 p.245 ~ p.252
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Superficial Bladder Cancer Treated with Bacillus Calmette-Guerin : Long-term Follow up Results
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Kim Yong-Woong
Wang Seo-Hwan
Yuk Seung-Mo
Han Dong-Seok
Roh An-Sik
Na Yong-Gil
Sul Chong-Koo
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Abstract
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To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy.
Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases.
The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively.
The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.
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KEYWORD
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Bladder neoplasms, Intravesical BCG instillation, Recurrence, Progression
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